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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
THOC2
All Species:
31.82
Human Site:
S1421
Identified Species:
53.85
UniProt:
Q8NI27
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.15
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q8NI27
NP_001075019.1
1593
182775
S1421
T
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Chimpanzee
Pan troglodytes
XP_001139291
1595
183045
S1423
T
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Rhesus Macaque
Macaca mulatta
XP_001086217
1593
182783
S1421
T
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Dog
Lupus familis
XP_538164
1593
182721
S1421
T
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Cat
Felis silvestris
Mouse
Mus musculus
B1AZI6
1594
182755
S1421
S
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Rat
Rattus norvegicus
XP_233081
1594
182711
S1421
T
H
P
S
P
S
H
S
S
T
V
K
D
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510761
1648
188085
S1476
H
S
S
P
S
H
S
S
T
V
K
D
N
N
L
Chicken
Gallus gallus
XP_420332
1593
182430
S1422
I
H
S
S
P
S
H
S
S
T
V
K
D
N
L
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_001003847
1504
172218
S1337
W
S
K
E
R
D
V
S
S
D
S
K
T
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_722763
1641
188490
T1465
R
H
G
D
G
V
E
T
V
D
L
V
G
S
T
Honey Bee
Apis mellifera
XP_393587
1354
156054
S1187
D
T
S
N
S
D
A
S
E
K
I
G
D
G
I
Nematode Worm
Caenorhab. elegans
NP_498392
1437
164369
K1266
T
P
S
P
P
P
A
K
K
T
R
I
V
D
R
Sea Urchin
Strong. purpuratus
XP_795489
1592
178912
P1396
G
D
H
W
G
G
A
P
S
S
E
L
D
S
W
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_173871
1804
205705
R1481
S
E
P
R
S
S
D
R
D
R
S
V
E
A
R
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99
99.9
99
N.A.
97.4
97.4
N.A.
85.8
88.1
N.A.
72.9
N.A.
39.7
43.1
29.5
48.7
Protein Similarity:
100
99.3
100
99.3
N.A.
98.9
99
N.A.
91.4
93.9
N.A.
83.4
N.A.
59
60.2
48.5
65.1
P-Site Identity:
100
100
100
100
N.A.
93.3
100
N.A.
13.3
80
N.A.
20
N.A.
13.3
13.3
20
20
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
33.3
86.6
N.A.
20
N.A.
26.6
33.3
20
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.1
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.4
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
22
0
0
0
0
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
8
0
8
0
15
8
0
8
15
0
8
65
8
0
% D
% Glu:
0
8
0
8
0
0
8
0
8
0
8
0
8
0
8
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
8
0
8
0
15
8
0
0
0
0
0
8
8
8
0
% G
% His:
8
58
8
0
0
8
50
0
0
0
0
0
0
0
0
% H
% Ile:
8
0
0
0
0
0
0
0
0
0
8
8
0
0
8
% I
% Lys:
0
0
8
0
0
0
0
8
8
8
8
58
0
8
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
0
8
8
0
0
58
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
8
0
0
0
0
0
0
0
0
8
15
0
% N
% Pro:
0
8
50
15
58
8
0
8
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
0
8
8
0
0
8
0
8
8
0
0
0
15
% R
% Ser:
15
15
29
50
22
58
8
72
65
8
15
0
0
58
0
% S
% Thr:
43
8
0
0
0
0
0
8
8
58
0
0
8
0
8
% T
% Val:
0
0
0
0
0
8
8
0
8
8
50
15
8
0
0
% V
% Trp:
8
0
0
8
0
0
0
0
0
0
0
0
0
0
8
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _